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Bad/Comprehensive Metabolizers, CYP2D6 The development with the Lively metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. About 7% in the inhabitants has decreased activity of your CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme technique. These people today are “poor metabolizers” of debrisoquine, dextromethorphan and tricycl